Solid Cancers after Hemopoietic Stem Cell Transplantation

Transplant recipients have been reported to have an increased risk of solid cancers.but most studies are small and have limited ability to evaluate the interaction of host, disease, and treatment-related factors. 1-- Overall, patients developed new solid cancers at twice the rate expected based on general population rates. the risk reached 3-fold among patients followed for 15 years or more after transplantation.
2-- Among patients irradiated at ages under 30 years, the relative risk of non-SCC was9 times that of nonirradiated patients,while the comparable risk for older patients was 1.1
3--Chronic graft-versus-host disease and male sex were the main determinants for risk of SCCallogeneic transplant survivors.Those irradiated at young ages, face increased risks of solid cancers,

(Blood. 2009;
113:1175-1183)

1.