Chemotherapy for early stage NSCLC(Completely resected)

CALGB-9633

1. NSCLC Stage-1b(T2No)
2. Complete resection /Resection followed by Adj chemo -Paclitaxel+Carboplatin
3. Survival was not significantly different in both the arms
4. Significant survival benifit for subjects with tumour size > 4cm

This brings about the following questions

1. Is the benifit of adjuvant chemo transient.
2. Should we propose adjuvant chemo as standard.
3. Is the combination of Pacli and Carboplatin the standard.
4. Role of biomarkers .
5. Should this data be incorporated in to the NCCN guidelines.

(JCO- Vol-26(31) Nov 2008.